Scientist II / Senior Scientist, ADME

Job Description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Scientist II / Senior Scientist, ADME will contribute to the design and execution of nonclinical pharmacokinetics/PKPD/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, Head of ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs.

Responsibilities

- Perform modeling and simulation, analyze PKPD and PK/TK data, and provide clear interpretation to inform program decisions.

- Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions.

- Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines.

- Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME.

- Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively.

- Maintain awareness of evolving best practices and regulatory expectations in ADME sciences.

Qualifications

- PhD in a relevant discipline with 0-3 years of industry experience in ADC PKPD and ADME, or MS with 5+ years relevant industry experience.

- Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred.

- Hands-on expertise in PKPD modeling, PK/TK analysis, and study design.

- Knowledge of both non-regulated and regulated bioanalysis.

Knowledge and Skills

- Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment.

- Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences.

- Collaborative approach with the ability to work across disciplines to achieve program goals.

Level and compensation will be commensurate with relevant experience.
Washington State Pay Range
$149,930-$203,961 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).